Incorporation of protein binding effects into likelihood ratio test for exome sequencing data
نویسندگان
چکیده
منابع مشابه
Incorporation of protein binding effects into likelihood ratio test for exome sequencing data
Statistical association studies are an important tool in detecting novel disease genes. However, for sequencing data, association studies confront the challenge of low power because of relatively small data sample size and rare variants. Incorporating biological information that reflects disease mechanism is likely to strengthen the association evidence of disease genes, and thus increase the p...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2016
ISSN: 1753-6561
DOI: 10.1186/s12919-016-0043-8